The NIH Blueprint seeks feedback from the scientific community about how to best continue to support neuroscience research over the next 10 years. Read more
BRAIN Initiative awardee Dr. Bryan Roth recently co-authored a paper in Neuron unveiling the second generation of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs), tools that will allow researchers to turn neuronal activity on and off in multiple cell types simultaneously. Read more
BRAIN Initiative awardee and Multi-Council Working Group member, Dr. David Tank, alongside three collaborators, recently received the European Brain Research Foundation “Brain Prize” for his contributions toward the development of two-photon microscopy. Read more
Karl Deisseroth, MD, PhD, will receive the 2015 Albany Medical Center Prize in Medicine and Biomedical Research , in honor of his pioneering role in the development of optogenetics , a technology for using light to control the activity of neurons, as well as for CLARITY , a method for transforming intact organs into transparent polymer gels to allow high-resolution visualization of biological structures. Dr. Deisseroth , a member of the BRAIN Working Group of the Advisory Committee to the NIH Director, will share the $500,000 prize with Xiaoliang Sunney Xie, PhD, a professor of chemistry and chemical biology at Harvard, who is a pioneer of single-molecule biophysical chemistry and its application to biology. Read more
The Advisory Committee to the NIH Director BRAIN Working Group recently published an article in Philosophical Transactions of the Royal Society B that discusses how the NIH BRAIN Initiative aims to produce neurotechnologies and tools that will support giant leaps forward in neuroscience research. Prior to the announcement of the first NIH-funded grants for BRAIN in September, the neuroscience experts who comprise the Working Group published the report “BRAIN 2025: A Scientific Vision” to help guide efforts at NIH relating to BRAIN. Convening these experts and gathering input from the broader community has enabled NIH to map a bold strategy to capitalize on each opportunity, milestone, and goal for the 12-year Initiative. Read more
The BRAIN Initiative℠ goal is to develop neurotechnologies that will enable scientists “to map the circuits of the brain, measure the fluctuating patterns of electrical and chemical activity flowing within those circuits, and understand how their interplay creates our unique cognitive and behavioral capabilities.” On March 4, 2015 the NIH BRAIN Multi-Council Working Group (MCWG) met for the second time to discuss current BRAIN Initiative activities, new funding opportunity announcements, and strategic planning for the future of the NIH BRAIN Initiative efforts. The BRAIN MCWG includes one member of the Advisory Council from each of the 10 NIH Institutes and Centers that contribute to the NIH BRAIN Initiative. In addition, at-large members are appointed to supplement MCWG expertise, and ex officio members are appointed from the Defense Advanced Research Projects Agency (DARPA), the Food and Drug Administration (FDA), the Intelligence Advanced Research Projects Activity (IARPA), and the National Science Foundation (NSF) – NIH’s four federal partners involved in The BRAIN Initiative℠. The purpose of the MCWG is to provide oversight for the long-term scientific vision of The BRAIN Initiative℠ and serve as a forum for initial “concept clearance” or the review of ideas for new initiatives before they become funding announcements. Read more
In 2013 President Obama asked the Presidential Commission on Bioethics to review the ethical issues associated with the conduct and implications of neuroscience research. Their report, Gray Matters: Integrative Approaches for Neuroscience, Ethics and Society, outlines many of the key areas for thought, dialog and planning. A major recommendation of the Commission was that neuroethics should be integrated into the planning and scientific activity of The BRAIN Initiative℠. On November 3, 2014, the National Institutes of Health (NIH) followed up on the report by convening a panel experienced in the ethics of neuroscience to discuss research questions central to the mission of the multiple NIH neuroscience Institutes and Centers as well as BRAIN. This NIH Neuroethics meeting (watch the videocast) brought together three dozen researchers, clinicians, bioethicists, and leadership from the National Science Foundation, the Food and Drug Administration, and NIH to discuss neuroethics and identify five to ten high priority areas for NIH-supported research related to both the ethical conduct of neuroscience research and the ethical uses of applications stemming from that research.
On Wednesday, March 4, 2015, the BRAIN Multi-Council Working Group will meet at the Neuroscience Center Building (6001 Executive Boulevard Rockville, MD). The meeting agenda will include discussion of BRAIN research supported by the National Institutes of Health (NIH), neuroethics, and presentations on BRAIN-related activities supported by the four additional Federal agencies involved in The BRAIN InitiativeSM: the Defense Advanced Research Projects Agency (DARPA), the National Science Foundation (NSF), the Food and Drug Administration (FDA), and the Intelligence Advanced Research Projects Activity (IARPA). The meeting is open to the public and will be videocast live.
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) InitiativeSM is a bold undertaking aimed at revolutionizing our understanding of the human brain. Since its inception in April of 2013, it has grown to include five Federal agencies – the National Institutes of Health (NIH), National Science Foundation (NSF), Defense Advanced Research Projects Agency (DARPA), Food and Drug Administration (FDA), and Intelligence Advanced Research Projects Activity (IARPA). The President’s 2016 Budget proposes increasing federal funding for The BRAIN InitiativeSM from about $200 million in FY 2015 to more than $300 million in FY 2016.
Included in the President’s 2016 Budget is a proposed $135 million for the NIH to invest in The BRAIN InitiativeSM, which would be an increase of about $60 million over the FY 2015 BRAIN InitiativeSM appropriation for NIH. This investment will support a diverse set of projects with ambitious goals, including developing new devices to record and modulate activity in the human nervous system, revolutionizing human neuroimaging technologies to understand how individual cells and complex neural circuits interact in time and space, and modeling and analyzing the complex data that scientists obtain in their quest to understand how the brain works. Taken together, these research efforts aim to develop and apply cutting-edge technologies to create a dynamic picture of the brain in action, providing the critical knowledge base for researchers seeking new ways to treat, cure, and even prevent brain disorders.
The Foundation for the National Institutes of Health (FNIH) has awarded the 2015 Lurie Prize in Biomedical Sciences to Karl Deisseroth of Stanford University. Dr. Deisseroth, a member of the BRAIN Working Group of the Advisory Committee to the NIH Director, is being honored for leading the development of optogenetics, a technology for using light to control the activity of neurons, as well as for CLARITY, a method for transforming intact organs into transparent polymer gels to allow high-resolution visualization of biological structures.
Over the past decade, optogenetics has become a ubiquitous tool in neuroscience labs worldwide and has played an important role in hundreds of research papers investigating the basic function of neurons as well as defects in neural circuitry underlying diseases such as Parkinson’s, depression, and schizophrenia. Developed two years ago, CLARITY has already enabled scientists to observe molecular-level details of healthy brains and the brains of Alzheimer’s disease and autism patients.
In alignment with the BRAIN Initiative’s goal of training scientists to use next-generation neuroscience tools and techniques, Dr. Deisseroth, using a research supplement from NINDS, offers free three-day workshops on both optogenetics and CLARITY throughout the year.
The Lurie Prize recognizes outstanding achievement by a promising scientist age 52 or younger, and includes a $100,000 honorarium. Dr. Deisseroth will be presented with the prize May 20 in Washington, D.C.